Effect of salt on the formation of salt-bridges in β-hairpin peptides.
نویسندگان
چکیده
Salt-bridges ubiquitously form between oppositely charged moieties in proteins. Here we quantify changes in population of salt-bridged β-hairpin peptides due to added salt, and determine the thermodynamic driving forces and cooperativity of salt-bridge formation under these conditions. We find only a fraction of salt-bridged folded conformations at physiologically relevant salt concentrations.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 60 شماره
صفحات -
تاریخ انتشار 2014